Once the computer restarts, see if the mouse cursor appears on the screen. Use the Arrow key to select the Restart option and click on OK to restart the computer. Press Alt + F4 keys on the Keyboard to bring up the Shut Down dialog box. If you are using a USB Hub, remove the Mouse from USB Hub and plug it directly into the USB Port of the computer. To confirm, plug the Mouse/Receiver into another USB Port and see you can now see the Cursor or the Mouse Pointer appearing on the scree of the computer. The problem of Mouse Pointer Disappearing might be due to the USB Port on your computer having a problem connecting to the Mouse due to a technical glitch or not at all working. This should help the computer to recognize the mouse and the Cursor or Mouse Pointer should now appear on the screen. If you are usinga wireless, remove its USB Reciever from the computer and re-connect it back again. If you are using a wired mouse, unplug it from the computer and connect it back again. In certain cases, the problem of Mouse Pointer Disappearing in Windows 10/11 is also known to occur due to the Mouse being disabled by an update installed on the computer, while it was in sleep mode.